Exercise And Weight Gain, Causes And Solutions

By admin / July 5, 2015

The cause is unknown. Currently, the disorder is best explained as a primary

Defect in chloride reabsorption in the ascending limb of the loop of Henle. The

Resultant decrease in sodium chloride reabsorption in this portion of the loop

Reduces medullary hypertonicity, perhaps explaining the concentrating defect.

The defect in chloride reabsorption presents extra sodium chloride to the distal

Tubule, where sodium is reabsorbed in exchange for potassium; the result is

Urinary potassium wasting. The induced hypokalemia stimulates the synthesis of

Prostaglandins (which may account for the vascular insensitivity to pressor

Agents and the defect in platelet aggregation); these, in turn, activate the

Renin-angiotensin-aldosterone system by increasing renin release and by

Stimulating aldosterone synthesis. The latter exacerbates renal potassium

Wasting.

CLINICAL MANIFESTATIONS.

A severe form of Bartter syndrome (sometimes called hyperprostaglandin E

Syndrome) may afflict newborns. It is characterized by polyhydramnios,

Prematurity, dehydration secondary to marked urinary sodium, potassium and water

Loss, and growth failure; hypercalciuria and nephrocalcinosis are common. Young

Children typically present with growth failure, muscle weakness, constipation,

And polyuria. Older children have muscle weakness or cramps and carpool.